abstract：:The vitamin D signal transduction system involves a series of cytochrome P450-containing sterol hydroxylases to generate and degrade the active hormone, 1α,25-dihydroxyvitamin D3, which serves as a ligand for the vitamin D receptor-mediated transcriptional gene expression described in companion articles in this review...

journal_title：Journal of lipid research

authors： Jones G,Prosser DE,Kaufmann M

更新日期：2014-01-01 00:00:00

abstract：:Insulin resistance (IR) is associated with elevated plasma levels of triglyceride-rich lipoproteins (TRLs) of intestinal origin. However, the mechanisms underlying the overaccumulation of apolipoprotein (apo)B-48-containing TRLs in individuals with IR are not yet fully understood. This study examined the relationships...

journal_title：Journal of lipid research

authors： Couture P,Tremblay AJ,Kelly I,Lemelin V,Droit A,Lamarche B

更新日期：2014-01-01 00:00:00

abstract：:none. ...

journal_title：Journal of lipid research

authors： Davidson WS

更新日期：2013-12-09 00:00:00

abstract：:Membrane-protein interaction plays key roles in a wide variety of biological processes. Although various methods have been employed to measure membrane binding of soluble proteins, a robust high-throughput assay that is universally applicable to all proteins is lacking at present. Here we report a new fluorescence que...

journal_title：Journal of lipid research

authors： Kim H,Afsari HS,Cho W

更新日期：2013-12-01 00:00:00

abstract：:Recent findings described the role of CD36-mediated signaling in regulating cellular calcium and the release of various bioactive molecules, including the prostaglandins, neurotransmitters, cholecystokinin, and secretin. Here we document the role of CD36 in the secretion of hepatic VLDL. CD36 deletion resulted in 60% ...

journal_title：Journal of lipid research

authors： Nassir F,Adewole OL,Brunt EM,Abumrad NA

更新日期：2013-11-01 00:00:00

abstract：:Expression of bile salt export pump (BSEP) is regulated by the bile acid/farnesoid X receptor (FXR) signaling pathway. Two FXR isoforms, FXRα1 and FXRα2, are predominantly expressed in human liver. We previously showed that human BSEP was isoform-dependently regulated by FXR and diminished with altered expression of F...

journal_title：Journal of lipid research

authors： Song X,Chen Y,Valanejad L,Kaimal R,Yan B,Stoner M,Deng R

更新日期：2013-11-01 00:00:00

abstract：:Blood levels of lipoprotein cholesterol and triglycerides (TGs) are highly heritable and are major risk factors for cardiovascular disease (CVD). Approximately 100 lipid-associated loci have been identified in populations of European ancestry. We performed a genome-wide association study of lipid traits in 1,782 Filip...

journal_title：Journal of lipid research

authors： Wu Y,Marvelle AF,Li J,Croteau-Chonka DC,Feranil AB,Kuzawa CW,Li Y,Adair LS,Mohlke KL

更新日期：2013-11-01 00:00:00

abstract：:Lipid modifications aid in regulating (and misregulating) protein function and localization. However, efficient methods to screen for a lipid's ability to modify proteins are not readily available. We present a strategy to identify protein-reactive lipids and apply it to a neurodevelopmental disorder, Smith-Lemli-Opit...

journal_title：Journal of lipid research

authors： Windsor K,Genaro-Mattos TC,Kim HY,Liu W,Tallman KA,Miyamoto S,Korade Z,Porter NA

更新日期：2013-10-01 00:00:00

abstract：:Tuberculosis is a major cause of mortality and morbidity due to infectious disease. However, current clinical diagnostic methodologies such as PCR, sputum culture, or smear microscopy are not ideal. Antibody-based assays are a suitable alternative but require specific antibodies against a suitable biomarker. Mycolic a...

journal_title：Journal of lipid research

authors： Chan CE,Zhao BZ,Cazenave-Gassiot A,Pang SW,Bendt AK,Wenk MR,MacAry PA,Hanson BJ

更新日期：2013-10-01 00:00:00

abstract：:We have performed plasma lipid profiling using liquid chromatography electrospray ionization tandem mass spectrometry on a population cohort of more than 1,000 individuals. From 10 μl of plasma we were able to acquire comparative measures of 312 lipids across 23 lipid classes and subclasses including sphingolipids, ph...

journal_title：Journal of lipid research

authors： Weir JM,Wong G,Barlow CK,Greeve MA,Kowalczyk A,Almasy L,Comuzzie AG,Mahaney MC,Jowett JB,Shaw J,Curran JE,Blangero J,Meikle PJ

更新日期：2013-10-01 00:00:00

abstract：:Autosomal recessive polycystic kidney disease (ARPKD) is a severe, monogenetically inherited kidney and liver disease. PCK rats carrying the orthologous mutant gene serve as a model of human disease, and alterations in lipid profiles in PCK rats suggest that defined subsets of lipids may be useful as molecular disease...

journal_title：Journal of lipid research

authors： Ruh H,Salonikios T,Fuchser J,Schwartz M,Sticht C,Hochheim C,Wirnitzer B,Gretz N,Hopf C

更新日期：2013-10-01 00:00:00

abstract：:Since spheroidal HDL particles (sHDL) are highly dynamic, molecular dynamics (MD) simulations are useful for obtaining structural models. Here we use MD to simulate sHDL with stoichiometries of reconstituted and circulating particles. The hydrophobic effect during simulations rapidly remodels discoidal HDL containing ...

journal_title：Journal of lipid research

authors： Segrest JP,Jones MK,Catte A

更新日期：2013-10-01 00:00:00

abstract：:Vitamin E is a naturally occurring fat-soluble antioxidant which has been proposed as a treatment for both primary and secondary protection against cardiovascular (CV) events. Promising data from observational epidemiological studies associating higher vitamin E dietary intake with lower risk of CV events have not bee...

journal_title：Journal of lipid research

authors： Vardi M,Levy NS,Levy AP

更新日期：2013-09-01 00:00:00

abstract：:MDCO-216, a complex of dimeric recombinant apoA-IMilano (apoA-IM) and palmitoyl-oleoyl-phosphatidylcholine (POPC), was administered to cynomolgus monkeys at 30, 100, and 300 mg/kg every other day for a total of 21 infusions, and effects on lipids, (apo)lipoproteins, and ex-vivo cholesterol efflux capacity were monitor...

journal_title：Journal of lipid research

authors： Kempen HJ,Gomaraschi M,Bellibas SE,Plassmann S,Zerler B,Collins HL,Adelman SJ,Calabresi L,Wijngaard PL

更新日期：2013-09-01 00:00:00

abstract：:Several studies in humans and animals suggest that LDL particle core enrichment in cholesteryl oleate (CO) is associated with increased atherosclerosis. Diet enrichment with MUFAs enhances LDL CO content. Steroyl O-acyltransferase 2 (SOAT2) is the enzyme that catalyzes the synthesis of much of the CO found in LDL, and...

journal_title：Journal of lipid research

authors： Melchior JT,Sawyer JK,Kelley KL,Shah R,Wilson MD,Hantgan RR,Rudel LL

更新日期：2013-09-01 00:00:00

abstract：:Ecdysteroids are potent developmental regulators that control molting, reproduction, and stress response in arthropods. In developing larvae, picogram quantities of individual ecdysteroids and their conjugated forms are present along with milligrams of structural and energy storage lipids. To enhance the specificity a...

journal_title：Journal of lipid research

authors： Lavrynenko O,Nedielkov R,Möller HM,Shevchenko A

更新日期：2013-08-01 00:00:00

abstract：:The secondary bile acid lithocholic acid (LCA) and its derivatives act as selective modulators of the vitamin D receptor (VDR), although their structures fundamentally differ from that of the natural hormone 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3)]. Here, we have determined the crystal structures of the ligand-binding...

journal_title：Journal of lipid research

authors： Masuno H,Ikura T,Morizono D,Orita I,Yamada S,Shimizu M,Ito N

更新日期：2013-08-01 00:00:00

abstract：:Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3β-hydroxysterol-Δ(7)-reductase (DHCR7). Although 14 oxysterols have been identified as the primary products of ...

journal_title：Journal of lipid research

authors： Xu L,Korade Z,Rosado DA Jr,Mirnics K,Porter NA

更新日期：2013-04-01 00:00:00

abstract：:Although the synthesis pathways of intracellular triacylglycerol (TAG) species have been well elucidated, assessment of the contribution of an individual pathway to TAG pools in different mammalian organs, particularly under pathophysiological conditions, is difficult, although not impossible. Herein, we developed and...

journal_title：Journal of lipid research

authors： Han RH,Wang M,Fang X,Han X

更新日期：2013-04-01 00:00:00

abstract：:The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro. Their role as physiological regulators under in vivo conditions is controversial, however. In the present work, we utilized a previousl...

journal_title：Journal of lipid research

authors： Ali Z,Heverin M,Olin M,Acimovic J,Lövgren-Sandblom A,Shafaati M,Båvner A,Meiner V,Leitersdorf E,Björkhem I

更新日期：2013-04-01 00:00:00

abstract：:Glycosylphosphatidylinositol (GPI) enriches GPI-anchored proteins (GPI-AP) in lipid rafts by intimate interaction of its lipid moiety with sphingolipids and cholesterol. In addition to such lipid-lipid interactions, it has been reported that GPI may interact with protein moiety linked to GPI and affect protein conform...

journal_title：Journal of lipid research

authors： Seong J,Wang Y,Kinoshita T,Maeda Y

更新日期：2013-04-01 00:00:00

abstract：:Cardiac triacylglycerol (TG) catabolism critically depends on the TG hydrolytic activity of adipose triglyceride lipase (ATGL). Perilipin 5 (Plin5) is expressed in cardiac muscle (CM) and has been shown to interact with ATGL and its coactivator comparative gene identification-58 (CGI-58). Furthermore, ectopic Plin5 ex...

journal_title：Journal of lipid research

authors： Pollak NM,Schweiger M,Jaeger D,Kolb D,Kumari M,Schreiber R,Kolleritsch S,Markolin P,Grabner GF,Heier C,Zierler KA,Rülicke T,Zimmermann R,Lass A,Zechner R,Haemmerle G

更新日期：2013-04-01 00:00:00

abstract：:We used a mouse C57BL/6J×CASA/Rk intercross to map a locus on chromosome 14 that displayed a gender-dependent effect on cholesterol absorption from the intestine. Studies in congenic animals revealed a complex locus with multiple operating genetic determinants resulting in alternating gender-dependent phenotypic effec...

journal_title：Journal of lipid research

authors： Wong WP,Altemus JB,Hester JF,Chan ER,Côté JF,Serre D,Sehayek E

更新日期：2013-03-01 00:00:00

abstract：:Delta-5 and delta-6 desaturases (D5D and D6D) are key enzymes in endogenous synthesis of long-chain PUFAs. In this sample of healthy subjects (n = 310), genotypes of single nucleotide polymorphisms (SNPs) rs174537, rs174561, and rs3834458 in the FADS1-FADS2 gene cluster were strongly associated with proportions of LC-...

journal_title：Journal of lipid research

authors： Al-Hilal M,Alsaleh A,Maniou Z,Lewis FJ,Hall WL,Sanders TA,O'Dell SD,MARINA study team.

更新日期：2013-02-01 00:00:00

abstract：:Cellular cholesterol is known to be under homeostatic control in nonsteroidogenic cells, and this intrigued us to understand how such control works in steroidogenic cells that additionally use cholesterol for steroid hormone synthesis. We employed primary culture of rat ovarian granulosa cells to study how steroidogen...

journal_title：Journal of lipid research

authors： Lai WA,Yeh YT,Lee MT,Wu LS,Ke FC,Hwang JJ

更新日期：2013-02-01 00:00:00

abstract：:Estimation of low-density lipoprotein cholesterol (LDL-C) using the Friedewald (FR) formula is often inaccurate when triglycerides are elevated or VLDL particle composition is altered. We hypothesized that LDL-C estimation by the FR formula and other measurement methods might also be inaccurate in individuals treated ...

journal_title：Journal of lipid research

authors： Davidson M,Liu SX,Barter P,Brinton EA,Cannon CP,Gotto AM Jr,Leary ET,Shah S,Stepanavage M,Mitchel Y,Dansky HM

更新日期：2013-02-01 00:00:00

abstract：:Mammalian spermatogenesis is a complex developmental program in which a diploid progenitor germ cell transforms into highly specialized spermatozoa. One intriguing aspect of sperm production is the dynamic change in membrane lipid composition that occurs throughout spermatogenesis. Cholesterol content, as well as its ...

journal_title：Journal of lipid research

authors： Keber R,Rozman D,Horvat S

更新日期：2013-01-01 00:00:00

abstract：:Ceramides play an essential role in modulating immune signaling pathways and proinflammatory cytokine production in response to infectious pathogens, stress stimuli, or chemotherapeutic drugs. In this study, we demonstrated that Aggregatibacter actinomycetemcomitans, the pathogen for aggressive periodontitis, induced ...

journal_title：Journal of lipid research

authors： Yu H,Valerio M,Bielawski J

更新日期：2013-01-01 00:00:00

abstract：:Thioesterase superfamily member 1 (Them1; synonyms acyl-CoA thioesterase 11 and StarD14) is highly expressed in brown adipose tissue and limits energy expenditure in mice. Them1 is a putative fatty acyl-CoA thioesterase that comprises tandem hot dog-fold thioesterase domains and a lipid-binding C-terminal steroidogeni...

journal_title：Journal of lipid research

authors： Han S,Cohen DE

更新日期：2012-12-01 00:00:00

abstract：:Mitochondrial cholesterol is maintained within a narrow range to regulate steroid and oxysterol synthesis and to ensure mitochondrial function. Mitochondria acquire cholesterol through several pathways from different cellular pools. Here we have characterized mitochondrial import of endosomal cholesterol using Chinese...

journal_title：Journal of lipid research

authors： Kennedy BE,Charman M,Karten B

更新日期：2012-12-01 00:00:00

abstract：:The mixed dyslipidemia phenotype is characterized by elevated triglycerides (TG), low HDL cholesterol (HDL-C), increased ApoB levels, and premature coronary atherosclerosis. Fibrate-statin combination therapy reduces ApoB levels and coronary events in the mixed dyslipidemia population. We sought to identify gene-gene ...

journal_title：Journal of lipid research

authors： Ma L,Ballantyne CM,Belmont JW,Keinan A,Brautbar A

更新日期：2012-11-01 00:00:00

abstract：:Wax esters are neutral lipids exhibiting desirable properties for lubrication. Natural sources have traditionally been whales. Additionally some plants produce wax esters in their seed oil. Currently there is no biological source available for long chain length monounsaturated wax esters that are most suited for indus...

journal_title：Journal of lipid research

authors： Heilmann M,Iven T,Ahmann K,Hornung E,Stymne S,Feussner I

更新日期：2012-10-01 00:00:00

abstract：:The effects of androgens on cardiovascular disease (CVD) risk in men remain unclear. To better characterize the relationship between androgens and HDL, we investigated the effects of testosterone replacement on HDL protein composition and serum HDL-mediated cholesterol efflux in hypogonadal men. Twenty-three older hyp...

journal_title：Journal of lipid research

authors： Rubinow KB,Vaisar T,Tang C,Matsumoto AM,Heinecke JW,Page ST

更新日期：2012-07-01 00:00:00

abstract：:Endothelial dysfunction is a key step in atherosclerosis development. Our recent studies suggested that oxLDL-induced increase in endothelial stiffness plays a major role in dyslipidemia-induced endothelial dysfunction. In this study, we identify oxysterols, as the major component of oxLDL, responsible for the increas...

journal_title：Journal of lipid research

authors： Shentu TP,Singh DK,Oh MJ,Sun S,Sadaat L,Makino A,Mazzone T,Subbaiah PV,Cho M,Levitan I

更新日期：2012-07-01 00:00:00

abstract：:A higher incidence of coronary artery disease is associated with a lower level of HDL-cholesterol. We searched for genetic loci influencing HDL-cholesterol in F2 mice from a cross between MRL/MpJ and SM/J mice. Quantitative trait loci (QTL) mapping revealed one significant HDL QTL (Apoa2 locus), four suggestive QTL on...

journal_title：Journal of lipid research

authors： Leduc MS,Blair RH,Verdugo RA,Tsaih SW,Walsh K,Churchill GA,Paigen B

更新日期：2012-06-01 00:00:00

abstract：:Agonist-induced lipolysis of adipose fat is robustly inhibited by insulin or by feedback inhibition by the long-chain fatty acids (LCFA) produced during lipolysis. However, the mode of action of LCFA in suppressing adipose lipolysis is not clear. β,β'-Tetramethyl hexadecanedioic acid (Mββ/ EDICA16) is a synthetic LCFA...

journal_title：Journal of lipid research

authors： Kalderon B,Azazmeh N,Azulay N,Vissler N,Valitsky M,Bar-Tana J

更新日期：2012-05-01 00:00:00

abstract：:The extent of hypercholesterolemia varies considerably in patients with familial hypercholesterolemia (FH). We hypothesized that the variability of the FH phenotype might be partly explained by variation in proprotein convertase subtilisin kexin type 9 (PCSK9) activity. Individuals between 18 and 53 years of age who h...

journal_title：Journal of lipid research

authors： Huijgen R,Fouchier SW,Denoun M,Hutten BA,Vissers MN,Lambert G,Kastelein JJ

更新日期：2012-05-01 00:00:00

abstract：:Prostaglandin (PG)E(2) is relevant in tumor biology, and interactions between tumor and stroma cells dramatically influence tumor progression. We tested the hypothesis that cross-talk between head and neck squamous cell carcinoma (HNSCC) cells and fibroblasts could substantially enhance PGE(2) biosynthesis. We observe...

journal_title：Journal of lipid research

authors： Alcolea S,Antón R,Camacho M,Soler M,Alfranca A,Avilés-Jurado FX,Redondo JM,Quer M,León X,Vila L

更新日期：2012-04-01 00:00:00

abstract：:Ursodeoxycholic acid (UDCA, ursodiol) is used to prevent damage to the liver in patients with primary biliary cirrhosis. The drug also prevents the progression of colorectal cancer and the recurrence of high-grade colonic dysplasia. However, the molecular mechanism by which UDCA elicits its beneficial effects is not e...

journal_title：Journal of lipid research

authors： Fang C,Filipp FV,Smith JW

更新日期：2012-04-01 00:00:00

abstract：:To study the mechanisms of hepatic HDL formation, we investigated the roles of ABCA1, ABCG1, and SR-BI in nascent HDL formation in primary hepatocytes isolated from mice deficient in ABCA1, ABCG1, or SR-BI and from wild-type (WT) mice. Under basal conditions, in WT hepatocytes, cholesterol efflux to exogenous apoA-I w...

journal_title：Journal of lipid research

authors： Ji A,Wroblewski JM,Cai L,de Beer MC,Webb NR,van der Westhuyzen DR

更新日期：2012-03-01 00:00:00